Sukhbaatar A, Sakamoto M, Mori S, Kodama T.
Analysis of tumor vascularization in a mouse model of metastatic lung cancer.
Scientific Reports 2019. DOI:10.1038/s41598-019-52144-2

Kato S, Shirai Y, Sakamoto M, Mori S, Kodama T
Use of a lymphatic drug delivery system and sonoporation to target malignant metastatic breast cancer cells proliferating in the marginal sinuses.
Scientific Reports. 2019 Sep 13;9(1):13242. ePub-PMID:31519920

Izumiyama T, Mori Y, Mori S, Mori N, Kodama T, Itoi E.
The effect of anti-IL-6 receptor antibody forthe treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructivearthritis and enthesitis.
BMC Musculoskeletal Disorders. 2019; 20:286. ePub-PMID:31200688

Kikuchi R, Sukhbaatar A, Sakamoto M, Mori S, Kodama T.
A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes.
Clinical and Translational Radiation Oncology 2019. DOI:10.1016/j.ctro.2019.05.002

Fujii H, Horie S, Sukhbaatar A, Mishra R, Sakamoto M, Mori S, Kodama T.
Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil.
Cancer Med. 2019 May;8(5):2241-2251. ePub-PMID:30945479

Iwamura R, Sakamoto M, Mori S, Kodama T.
Imaging of the mouse lymphatic sinus during early-stage lymph node metastasis using intranodal lymphangiography with X-ray micro-computed tomography.
Mol Imaging Biol. 2019 Oct;21(5):825-834. ePub-PMID:30607526

Sukhbaatar A, Mori S, Saiki Y, Takahashi T, Horii A, Kodama T.
Lymph node resection induces the activation of tumor cells in the lungs.
Cancer Sci. 2019 Feb;110(2):509-518. ePub-PMID:30499190



Kodama T, Mori S, Nose M.
Tumor cell invasion from the marginal sinus into extranodal veins during early-stage lymph node metastasis can be a starting point for hematogenous metastasis.
J Cancer Metastasis Treat 2018;4:56. DOI:10.20517/2394-4722.2018.61

Ouchi T, Sukhbaatar A, Horie S, Sakamoto M, Shiga K, Mori S, Kodama T.
Superselective Drug Delivery Using Doxorubicin-Encapsulated Liposomes and Ultrasound in a Mouse Model of Lung Metastasis Activation.
Ultrasound Med Biol. 2018 Aug;44(8):1818-1827. ePub-PMID:29793853

Zheng J, Jia L, Mori S, Kodama T.
Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes.
BMC Cancer. 2018 May 30;18(1):608. ePub-PMID:29848296

Fujii H, Horie S, Takeda K, Mori S, Kodama T.
Optimal range of injection rates for a lymphatic drug delivery system.
J Biophotonics. 2018 Aug;11(8):e201700401. ePub-PMID:29461015

Jadhav M, Kalhapurea RS, Rambharose S, Mocktar C, Singh S, Kodama T, Govender T.
Novel lipids with three C18-fatty acid chains and an amino acid head group for pH-responsive and sustained antibiotic delivery.
Chem Phys Lipids. 2018 Jan 2;212:12-25. ePub-PMID:29305156



Ncapayi V, Sundararajan P, Songca SP, Kodama T, Oluwafemi OS.
Green synthesis of MPA-capped CdTe/CdSe quantum dots at different pH and its effect on the cell viability of fibroblast histiocytoma cells.
Materials Letters. 2017; 209: 299-302. DOI:10.1016/j.matlet.2017.08.042

Tada A, Horie S, Mori S, Kodama T.
Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes.
Cancer Sci. 2017 Nov;108(11):2115-2121. ePub-PMID:28846190

Oladipo AO, Oluwafemi OS, Songca SP, Sukhbaatar A, Mori S, Okajima J, Komiya A, Maruyama S, Kodama T.
A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy.
Sci Rep. 2017 Apr 3;7:45459. ePub-PMID:28368042

Mikada M, Sukhbaatar A, Miura Y, Horie S, Sakamoto M, Mori S, Kodama T.
Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis.
Cancer Sci. 2017 May;108(5):846-852. ePub-PMID:28211204

Takeda K, Mori S, Kodama T.
Study of fluid dynamics reveals direct communications between lymphatic vessels and venous blood vessels in lymph nodes of mice.
J Immunol Methods. 2017 Jun;445:1-9. ePub-PMID:28237707

Matsuki D, Oladipo A, Horie S, Okajima J, Komiya A, Oluwafemi O, Maruyama S, Mori S, Kodama T.
Treatment of tumor in lymph nodes using near-infrared laser light-activated thermosensitive liposome-encapsulated doxorubicin and gold nanorods.
J Biophotonics. 2017 Dec;10(12):1676-1682. ePub-PMID:28417560

Sato T, Takemura T, Ouchi T, Mori S, Sakamoto M, Arai Y, Kodama T.
Monitoring of blood vessel density using contrast-enhanced high frequency ultrasound may facilitate early diagnosis of lymph node metastasis.
J Cancer. 2017 Feb 25;8(5):704-715. ePub-PMID:28382132

Ncapayi V, Sundararajan P, Songca SP, Kodama T, Oluwafemi OS.
Simple green synthesis of amino acid functionalised CdTe/CdSe/ZnSe core-multi shell with improved cell viability for cellular imaging.
Materials Letters. 2017; 189: 168-171. DOI:10.1016/j.matlet.2016.12.006

Mori N, Mugikura S, Takahashi S, Ito K, Takasawa C, Li L, Miyashita M, ko Kasajima A, Mori Y, Ishida T, Kodama T, Takase K.
Quantitative analysis of contrast-enhanced ultrasound imaging in invasive breast cancer: a novel technique to obtain histopathological information of microvessel density.
Ultrasound Med Biol. 2017 Mar;43(3):607-614. ePub-PMID:28041744



Fujikawa T, Egarashi R, Fujikawa S, Takeda K, Kodama T.
Extended Bernoulli equation, friction loss, and friction coefficient for microscopic Jeffery-Hamel flow with small Reynolds number up to O(1).
Journal of Fluid Science and Technology 2016;11(3): 1-12. DOI:10.1299/jfst.2016jfst0019

Kodama T, Matsuki D, Tada A, Takeda K, Mori S.
New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network.
Scientific Reports 2016 Sep 1;6:32506. ePub-PMID:27581921

Horie S, Suzuki Y, Kobayashi M, Kadonosono T, Kondoh S, Kodama T, Sato Y.
Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis.
Cancer Gene Ther. 2016 May; 23(5):133-41. ePub-PMID:27080222

Miura Y, Mikada M, Ouchi T, Horie S, Takeda K, Yamaki T, Sakamoto M, Mori S, Kodama T.
Early diagnosis of lymph node metastasis: importance of intranodal pressures.
Cancer Sci. 2016 Mar;107(3):224-32. ePub-PMID:26716604

Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer.
Eur Radiol. 2016 Feb;26(2):331-9. ePub-PMID:26024846



Ferraresi C, Parizotto NA, Pires de Sousa MV, Kaippert B, Huang YY, Koiso T, Bagnato VS, Hamblin MR.
Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation.
J Biophotonics. 2015 Sep;8(9):740-54. ePub-PMID:25378263

Kato S, Mori S, Kodama T.
A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound.
J Cancer. 2015 Oct 20;6(12):1282-94. ePub-PMID:26640589

Sugiura T, Matsuki D, Okajima J, Komiya A, Mori S, Maruyama S, Kodama T.
Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling.
Nano Research 2015, 8(12): 3842–3852. DOI:10.1007/s12274-015-0884-x

Ito K, Noro K, Yanagisawa Y, Sakamoto M, Mori S, Shiga K, Kodama T, Aoki T.
High-Accuracy Ultrasound Contrast Agent Detection Method for Diagnostic Ultrasound Imaging Systems.
Ultrasound Med Biol. 2015; 41(12): 3120-30. ePub-PMID:26411669

Shao L, Takeda K, Kato S, Mori S, Kodama T.
Communication between lymphatic and venous systems in mice.
J Immunol Methods. 2015 Sep;424:100-5. ePub-PMID:26009246
It was introduced on the "HighBeam Research (October 23, 2015)".

Sato T, Mori S, Sakamoto M, Arai Y, Kodama T.
Direct Delivery of a Cytotoxic Anticancer Agent into the Metastatic Lymph Node Using Nano/Microbubbles and Ultrasound.
PLoS One. 2015;10:e0123619. ePub-PMID:25897663

Sakata N, Sax N, Yoshimatsu G, Tsuchiya H, Kato S, Aoki T, Ishida M, Katayose Y, Egawa S, Kodama T, Unno M.
Enhanced Ultrasonography Using a Nano/Microbubble Contrast Agent for Islet Transplantation.
Am J Transplant. 2015 Jun;15(6): 1531–42. ePub-PMID:25846610

Shao L, Ouchi T, Sakamoto M, Mori S, Kodama T.
Activation of latent metastases in the lung after resection of a metastatic lymph node in a lymph node metastasis mouse model.
Biochem Biophys Res Commun. 2015;460:543-8. ePub-PMID:25824032

Kato S, Shirai Y, Kanzaki H, Sakamoto M, Mori S, Kodama T.
Delivery of Molecules to the Lymph Node via Lymphatic Vessels Using Ultrasound and Nano/Microbubbles.
Ultrasound Med Biol. 2015; 41(5):1411–21. ePub-PMID:25637527

Kodama T, Hatakeyama Y, Kato S, Mori S.
Visualization of flow fields in lymphatic vessels and lymph nodes using a mouse model to test a lymphatic drug delivery system.
Biomed Opt Express. 2015; 6(1):124-34. ePub-PMID:25657881

Tomita Y, Matsuura T, Kodama T.
Temporal effect of inertial cavitation with and without microbubbles on surface deformation of agarose S gel in the presence of 1-MHz focused ultrasound.
Ultrasonics. 2015 Jan;55:1-5. ePub-PMID:25130135



Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M.
Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.
Cancer Sci. 2014 Oct;105(10):1351-9. ePub-PMID:25098609

Sato T, Mori S, Arai Y, Kodama T.
The combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is efficient in the treatment of experimental tumors in mouse lymph nodes.
Ultrasound Med Biol. 2014 Mar 19, 40(6):1237-1249. ePub-PMID:24656719

Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo S, Ohkubo Y, Fukumoto M.
Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors.
Cancer Med. 2014 Apr;3(2):310-21. ePub-PMID:24464839

Saito K, Mori S, Date F, Ono M.
Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2.
Autoimmunity. 2014 Feb;47(1):13-22. ePub-PMID:24392721



Kochi T, Imai Y, Takeda A, Watanabe Y, Mori S, Tachi M, Kodama T.
Characterization of the Arterial Anatomy of the Murine Hindlimb: Functional Role in the Design and Understanding of Ischemia Models.
PLoS One. 2013 Dec 30;8(12):e84047.ePub-PMID:24386328

Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T,
Egawa S, Unno M.

Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging,
and ultrasonography.
Islets. 2013 Nov 14;5(5):179-87. ePub-PMID: 24231367

Okuno T, Kato S, Hatakeyama Y, Okajima J, Maruyama S, Sakamoto M, Mori S, Kodama T.
Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light.
J Control Release. 2013 Oct 19, 172(3): 879-884. ePub-PMID: 24144919

Horie S, Chen R. Li L, Mori S, Kodama T.
Contrast-enhanced high-frequency ultrasound imaging of early stage liver metastasis in a preclinical mouse model.
Cancer Lett. 2013 Oct 10;339(2):208-13. ePub- PMID: 23791880

Kanzaki H, Shinohara F, Kajiya M, Kodama T.
The Keap1/Nrf2 Axis Plays A Role In Osteoclast Differentiation By Regulating Intracellular ROS Signaling.
J Biol Chem. 2013 Aug 9;288(32):23009-20. ePub-PMID: 23801334

Li L, Mori S, Kodama M, Sakamoto M, Takahashi S, Kodama T.
Enhanced sonographic imaging to diagnose lymph node metastasis: importance of blood vessel volume and density.
Cancer Res. 2013; 73(7): 2082-2092. Jan 18. ePub- PMID: 23333937

Saito K, Mori S, Date F, Ono M.
Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.
Autoimmunity. 2013 Jun;46(4):231-7. ePub-PMID: 23301790

Nose M, Komori H, Miyazaki T, Mori S.
Genomics of vasculitis: lessons from mouse models.
Ann Vasc Dis. 2013;6(1):16-21. ePub-PMID: 23641278

Shao L, Mori S, Yagishita Y, Okuno T, Hatakeyama Y, Sato T, Kodama T.
Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer.
J Immunol Methods. 2013 Mar 29;389(1-2):69-78. ePub -PMID: 23328410

Li L, Mori S, Sakamoto M, Takahashi S, Kodama T.
Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities.
PLoS One. 2013;8(2):e55797. ePub-PMID:23405215

Sax N, Kodama T.
Optimization of acoustic liposomes for improved in vitro & in vivo stability.
Pharm Res. 2013 Jan;30(1):218-24. ePub-PMID: 22945302



Kodama T, Tomita N, Yagishita Y, Horie S, Funamoto K, Hayase T, Sakamoto M, Mori S.
Volumetric and angiogenic evaluation of antitumor effects with acoustic liposome and high-frequency ultrasound.
Cancer Res. 2011 Nov 15;71(22):6957-64. Epub 2011 Oct 7. ePub-PMID:21983036

Horie S, Watanabe Y, Ono M, Mori S, Kodama T.
Evaluation of antitumor effects following tumor necrosis factor-α gene delivery using nanobubbles and ultrasound.
Cancer Sci. 2011 Nov;102(11):2082-9. doi: 10.1111/j.1349-7006.2011.02056.x. 2011 Sep 16.

Kobayashi K, Kodama T, Takahira H.
Shock wave-bubble interaction near soft and rigid boundaries during lithotripsy: numerical analysis by the improved ghost fluid method.
Phys Med Biol. 2011 Oct 7;56(19):6421-40. 2011 Sep 15. ePub-PMID:21918295

Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M.
Monitoring transplanted islets by high-frequency ultrasound.
Islets. 2011 Sep-Oct;3(5):259-66. 2011 Sep 1. ePub-PMID:21795859

du Toit LC, Govender T, Pillay V, Choonara YE, Kodama T.
Investigating the effect of polymeric approaches on circulation time and physical properties of nanobubbles.
Pharm Res. 2011 Mar;28(3):494-504. 2010 Dec 23. ePub-PMID:21181551



Horie S, Watanabe Y, Chen R, Mori S, Matsumura Y, Kodama T.
Development of localized gene delivery using a dual-intensity ultrasound system in the bladder.
Ultrasound Med Biol. 2010 Nov;36(11):1867-75. 2010 Sep 26. ePub-PMID:20870350

Fujisawa S, Arakawa H, Suzuki R, Maruyama K, Kodama T, Yasunaga M, Koga Y, Matsumura Y.
Optimum conditions of ultrasound-mediated destruction of bubble liposome for siRNA transfer in bladder cancer.
Ther Deliv. 2010 Aug;1(2):247-55. ePub-PMID:22816131

Koshiyama K, Yano T, Kodama T.
Self-organization of a stable pore structure in a phospholipid bilayer.
Phys Rev Lett. 2010 Jul 2;105(1):018105. 2010 Jul 2. ePub-PMID:20867485

Kodama T, Aoi A, Watanabe Y, Horie S, Kodama M, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M.
Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound.
Ultrasound Med Biol. 2010 Jul;36(7):1196-205. ePub-PMID:20620706

Tomita Y, Uchikoshi R, Inaba T, Kodama T.
Ultrasound induced microbubble destruction and cavitation bubble generation.
Japanese Journal of multiphase flow. 2010; 24(2): 162-168 (in Japanese).

Watanabe Y, Horie S, Funaki Y, Kikuchi Y, Yamazaki H, Ishii K, Mori S, Vassaux G, Kodama T.
Delivery of Na/I symporter gene into skeletal muscle using nanobubbles and ultrasound:
visualization of gene expression by PET.
J Nucl Med. 2010 Jun;51(6):951-8. 2010 May 19. ePub-PMID:20484436

Kodama T, Tomita N, Horie S, Sax N, Iwasaki H, Suzuki R, Maruyama K, Mori S, Manabu F.
Morphological study of acoustic liposomes using transmission electron microscopy.
J Electron Microsc (Tokyo). 2010;59(3):187-96. 2009 Nov 11. ePub-PMID:19906662



Chen R, Chiba M, Mori S, Fukumoto M, Kodama T.
Periodontal gene transfer by ultrasound and nano/microbubbles.
J Dent Res. 2009 Nov;88(11):1008-13. ePub-PMID:19828888
William J. Gies Award

Kodama T, Tomita Y, Watanabe Y, Koshiyama K, Yano T, Fujikawa S.
Cavitation bubbles mediated molecular delivery during sonoporation.
Journal of Biomechanical Science and Engineering. 2009; 4: 124-140.

Suzuki R, Oda Y, Utoguchi N, Namai E, Taira Y, Okada N, Kadowaki N, Kodama T, Tachibana K, Maruyama K.
A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy.
J Control Release. 2009 Feb 10;133(3):198-205. 2008 Oct 31. ePub-PMID:19000727


Yagishita Y, Kodama T.
Delivery of genes/therapeutic molecules uisng acoustic liposome and ultrasound.
Vascular Biology & Medicine. 2009; 10(4): 91-98.



Watanabe Y, Aoi A, Horie S, Tomita N, Mori S, Morikawa H, Matsumura Y, Vassaux G, Kodama T.
Low-intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin.
Cancer Sci. 2008 Dec;99(12):2525-31. 2008 Nov 17. ePub-PMID:19018767

Koshiyama K, Kodama T, Yano T, Fujikawa S.
Molecular dynamics simulation of structural changes of lipid bilayers induced by shock waves: Effects of incident angles.
Biochim Biophys Acta. 2008 Jun;1778(6):1423-8. 2008 Mar 20. ePub-PMID:18405658

Aoi A, Watanabe Y, Mori S, Takahashi M, Vassaux G, Kodama T.
Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound.
Ultrasound Med Biol. 2008 Mar;34(3):425-34. 2007 Dec 21. ePub-PMID:18096302



Takahashi M, Kido K, Aoi A, Furukawa H, Ono M, Kodama T.
Spinal gene transfer using ultrasound and microbubbles.
J Control Release. 2007 Feb 12;117(2):267-72. 2006 Nov 6. ePub-PMID:17166615



Kodama T, Tomita Y, Koshiyama K, Blomley MJK.
Transfection effect of microbubbles on cells in superposed ultrasound waves and behavior of
cavitation bubble.
Ultrasound Med Biol. 2006 Jun;32(6):905-14. ePub-PMID:16785012

Koshiyama K, Kodama T, Yano T, Fujikawa S.
Structural change of lipid bilayer and water penetration induced by shock wave: molecular
dynamics simulations.
Biophys J. 2006 Sep 15;91(6):2198-205. ePub-PMID:16798798

Kodama T, Aoi A, Vassaux G, Mori S, Morikawa H, Koshiyama K, Yano T, Fujikawa S, Tomita Y.
A non-invasive tissue-specific molecular delivery method of cancer gene therapy.
Minim Invasive Ther Allied Technol. 2006;15(4):226-9. ePub-PMID:16966136

Kodama T, Koshiyama K, Tomita Y, Suzuki M, Yano T, Fujikawa S.
Interaction of impulsive oressures of cavitation bubbles with cell membrane during
sonoporation. AIP Conference Proceedings, 2006; 829: 34-38.

Koshiyama K, Kodama T, Yano T, Fujikawa S.
Molecular dynamics simulation of water pore formation in lipid bilayer induced by shock waves.
AIP Conference Proceedings, 2006; 829: 583-587.



Kodama T, Tan PH, Offiah I, George AJT, Partridge T, Cook T, Blomley MJK.
Delivery of oligodeoxynucleotides into human saphenous veins and the adjunct effect of
ultrasound and microbubbles.
Ultrasound in Medicine and Biology. 2005 Dec;31(12):1683-91. ePub-PMID:16344130

Suzuki M. Koshiyama K, Shinohara F. Mori S, Ono M, Tomita Y, Yano T, Fujikawa S,
Vassaux G, Kodama T.

Nanobubble enhanced drug susceptibility of cancer cells using ultrasound.
International Congress Series. 2005; 1284: 338-339.

Koshiyama K, Kodama T, Hamblin MR, Doukas AG, Yano T, Fujikawa S.
Molecular delivery into a lipid bilayer with a single shock wave using molecular dynamics simulation.
AIPConference Proceedings, 2005; 754: 104-106.