Archivements


 

2014

Journals / International Conference

Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M. Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance. Cancer Sci. 2014 Oct;105(10):1351-9. ePub-PMID:25098609

Tomita Y, Matsuura T, Kodama T. Temporal effect of inertial cavitation with and without microbubbles on surface deformation of agarose S gel in the presence of 1-MHz focused ultrasound. Ultrasonics. 2014 Aug 4. ePub-PMID:25130135

Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo S, Ohkubo Y, Fukumoto M. Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors. Cancer Med. 2014 Apr;3(2):310-21. ePub-PMID:24464839

Saito K, Mori S, Date F, Ono M. Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2. Autoimmunity. 2014 Feb;47(1):13-22. ePub-PMID:24392721

Sato T, Mori S, Arai Y, Kodama T. The combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is efficient in the treatment of experimental tumors in mouse lymph nodes. Ultrasound Med Biol. 2014 Mar 19, 40(6):1237-1249. ePub-PMID:24656719

T. Miyazaki , T. Inoue, Y. Shirosaki, M. Kawashita, T. Matsubara and A. Matsumine, "Bisphosphonate release profiles from magnetite microspheres", J. Biomater. Appl., in press.

M. Kawashita, Y. Yokohama, X. Y. Cui, T. Miyazaki and H. Kanetaka, "In vitro apatite formation and visible-light photocatalytic activity of Ti metal subjected to chemical and thermal treatments", Ceram. Int., in press. DOI 2014

M. Kawashita, J. Hayashi, T. Kudo, H. Kanetaka, Z. Li, T. Miyazaki and M. Hashimoto, "MC3T3-E1 and RAW264.7 cell response to hydroxyapatite and alpha-type alumina adsorbed with bovine serum albumin", J. Biomed. Mater. Res., 102A, 1880-1886 (2014). DOI

T. Miyazaki, T. Suda, Y. Shirosaki and M. Kawashita, "Fabrication of yttrium phosphate microcapsules by an emulsion route for in situ cancer radiotherapy", J. Med. Biol. Eng., 34, 14-17 (2014). DOI

M. Kawashita, J. Hayashi, Z. Li, T. Miyazaki, M. Hashimoto, H. Hihara and H. Kanetaka, "Adsorption characteristics of bovine serum albumin onto alumina with a specific crystalline structure", J. Mater Sci: Mater. Med., 25, 453-459 (2014). DOI

Iwase Yumiko, Yumita Nagahiko, Imaizumi Takahiro, Sakurazawa Ai, Kaya Yuuka, Nishi Koti, Shin-ichiro Umemura, Chen Fu-Shih, Momose Yasunori, and Ikeda Toshihiko , "SONODYNAMICALLY INDUCED ANTICANCER EFFECTS BY FUNCTIONALIZED FULLERENES", DRUG METABOLISM REVIEWS, vol. 45, no. S1, pp. 98-98, Jan 2014.



2013

Kochi T, Imai Y, Takeda A, Watanabe Y, Mori S, Tachi M, Kodama T. Characterization of the Arterial Anatomy of the Murine Hindlimb: Functional Role in the Design and Understanding of Ischemia Models. PLoS One. 2013 Dec 30;8(12):e84047.ePub-PMID:24386328

Okuno T, Kato S, Hatakeyama Y, Okajima J, Maruyama S, Sakamoto M, Mori S, Kodama T. Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light. J Control Release. 2013 Oct 19, 172(3): 879-884. ePub-PMID: 24144919

Horie S, Chen R. Li L, Mori S, Kodama T. Contrast-enhanced high-frequency ultrasound imaging of early stage liver metastasis in a preclinical mouse model. Cancer Lett. 2013 Oct 10;339(2):208-13. ePub- PMID: 23791880

Kanzaki H, Shinohara F, Kajiya M, Kodama T. The Keap1/Nrf2 Axis Plays A Role In Osteoclast Differentiation By Regulating Intracellular ROS Signaling. J Biol Chem. 2013 Aug 9;288(32):23009-20. ePub-PMID: 23801334

Li L, Mori S, Kodama M, Sakamoto M, Takahashi S, Kodama T. Enhanced sonographic imaging to diagnose lymph node metastasis: importance of blood vessel volume and density. Cancer Res. 2013; 73(7): 2082-2092. Jan 18. ePub- PMID: 23333937

Saito K, Mori S, Date F, Ono M. Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. Autoimmunity. 2013 Jun;46(4):231-7. ePub-PMID: 23301790

Nose M, Komori H, Miyazaki T, Mori S. Genomics of vasculitis: lessons from mouse models. Ann Vasc Dis. 2013;6(1):16-21. ePub-PMID: 23641278

Shao L, Mori S, Yagishita Y, Okuno T, Hatakeyama Y, Sato T, Kodama T. Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer. J Immunol Methods. 2013 Mar 29;389(1-2):69-78. ePub -PMID: 23328410

Li L, Mori S, Sakamoto M, Takahashi S, Kodama T. Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities. PLoS One. 2013;8(2):e55797. ePub-PMID:23405215

Sax N, Kodama T. Optimization of acoustic liposomes for improved in vitro & in vivo stability. Pharm Res. 2013 Jan;30(1):218-24. ePub-PMID: 22945302

Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Egawa S, Unno M. Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography. Islets. 2013 Nov 14;5(5). ePub-PMID: 24231367

T. Yokoi, M. Kawashita and C. Ohtsuki, "Effects of polymer concentration on the morphology of calcium phosphate crystals formed in polyacrylamide hydrogels", J. Cryst. Growth, 383, 166-171 (2013). DOI

H. Shibata, T. Yokoi, T. Goto, I. Y. Kim, M. Kawashita, K. Kikuta and C. Ohtsuki, "Calcification behavior of needle-like hydroxyapatite crystals with various aspect ratios in a solution mimicking in vivo condition", J. Ceram. Soc. Japan, 121, 807-812 (2013) DOI.

H. Shima, T. Kawai, Y. Matsushima, H. Unuma, K. Kawamura, Z. Li and M. Kawashita, "Magnetite fine particles highly loaded PMMA microspheres for hyperthermia of deep-seated cancer", J. Ceram. Soc. Japan, 121, 802-806 (2013). DOI

Z. Li, T. Miyazaki and M. Kawashita, "Preparation and in vitro apatite-forming ability of porous and non-porous titania microspheres", J. Ceram. Soc. Japan, 121, 782-787 (2013). DOI

T. Yokoi, M. Kawashita and C. Ohtsuki, "Biomimetic mineralization of calcium phosphates in polymeric hydrogels containing carboxyl groups", J. Asian Ceram. Soc., 1, 155-162 (2013). DOI

M. Kawashita, N. Matsui, T. Miyazaki and H. Kanetaka, "Effect of ammonia or nitric acid treatment on surface structure, in vitro apatite formation, and visible-light photocatalytic activity of bioactive titanium metal", Colloids Surf. B, 111, 503-508 (2013). DOI

M. Kawashita, K. Nakamura, T. Miyazaki and H. Kanetaka, "Structure of yttrium and phosphorus-containing microspheres prepared by spray dry method", Int. J. Mater. Chem., 3, 16-20 (2013). PDF

T. Miyazaki, S. Anan, E. Ishida and M. Kawashita, "Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia", J. Mater. Sci.: Mater. Med., 24, 1125-1129 (2013). DOI

M. Kawashita, N. Matsui, T. Miyazaki and H. Kanetaka, "Effect of autoclave and hot water treatments on surface structure and in vitro apatite-forming ability of NaOH- and heat-treated bioactive titanium metal", Mater. Trans., 54, 811-816 (2013). DOI

T. Yokoi, M. Kamitakahara, M. Kawashita and C. Ohtsuki, "Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids", J. Ceram. Soc. Japan, 121, 219-225 (2013). DOI

Yumita Nagahiko, Iwase Yumiko, Imaizumi Takahiro, Sakurazawa Ai, Kaya Yuuka, Nishi Koti, Ikeda Toshihiko, Shin-Ichiro Umemura, Chen Fu-Shih, and Momose Yasunori , "Sonodynamically-induced Anticancer Effects by Functionalized Fullerenes", ANTICANCER RESEARCH, vol. 33, no. 8, pp. 3145-3151, Aug 2013.

S. Yoshizawa, J. Yasuda, and S. Umemura , "High-speed observation of bubble cloud generation near a rigid wall by second-harmonic superimposed ultrasound,"Journal of the Acoustical Society of America, vol. 134, no. 2, pp. 1515-1520, 2013.

T. Shishitani, R. Matsuzawa, Shin Yoshizawa , and Shin-ichiro Umemura , "Changes in backscatter of liver tissue due to thermal coagulation induced by focused ultrasound ," Journal of the Acoustical Society of America, vol. 134, no. 2, pp. 1724-1730, 2013

S. Umemura, S. Yoshizawa, Ryo Takagi, Yuta Inaba, and Jun Yasuda , " Enhancement of Focused Ultrasound Treatment by Acoustically Generated Microbubbles,"Japanese Journal of Applied Physics, vol. 52, pp. 07HA02 1-6, 2013.

Ayumu Asai, Hiroki Okano, Shin Yoshizawa , and Shin-ichiro Umemura , " Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles ,"Japanese Journal of Applied Physics, vol. 52, pp. 07HF02 1-6, 2013.

Soichiro Harigane, Ryo Miyasaka, Shin Yoshizawa , and Shin-ichiro Umemura , " Optical Phase Contrast Mapping of Highly Focused Ultrasonic Fields,"Japanese Journal of Applied Physics, vol. 52, pp. 07HF07 1-5, 2013.

Kotaro Nakamura, Ayumu Asai, Hiroshi Sasaki, Shin Yoshizawa , and Shin-ichiro Umemura , " Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by Array Transducer Driven by 32 Channel Drive Circuits,"Japanese Journal of Applied Physics, vol. 52, pp. 07HF10 1-5, 2013.

Jun Yasuda, Ayumu Asai, Shin Yoshizawa , and Shin-ichiro Umemura , "Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure-Emphasized Waves,"Japanese Journal of Applied Physics, vol. 52, pp. 07HF11 1-6, 2013.

H. Aoki, K. Ichizuka, M. Ichihara, R. Matsuoka, J. Hasegawa, T. Okai and S. Umemura, "Application of high-intensity focused ultrasound for fetal therapy: experimental study using an animal model of lower urinary tract obstruction,"Journal of Medical Ultrasonics, vol. 40, no. 2, pp. 107-110, 2013.

T. Okai, K. Ichizuka, J. Hasegawa, R. Matsuoka, M. Nakamura, K. Shimodaira, A. Sekizawa, M. Kushima and S. Umemura, "First successful case of non-invasive in-utero treatment of twin reversed arterial perfusion sequence by high-intensity focused ultrasound,"Ultrasound in Obstetrics & Gynecology, vol. 42, pp. 112-114, 2013.

Ishizaki, K. Ishii, S. Matsuyama, S. Koshio, S. Yamauchi, K. Kusano, Y. Nozawa, M. Karahashi, S. Oshikawa, K. Kikuchi , K. Watanabe, S. Itoh, K. Kasahara, S. Toyama, Y. Suzuki, F. Fujishiro, N. Osada, H. Arai, A. Terakawa, Y. Kikuchi and H. Takahashi Concentration of Cs in plants and Water for the radioactive pollution due to Fukushima first nuclear power plant disaster.[Nuclear Instruments and Methods in Physics Research B,(2013),xxx]A.

H. Arai, K. Ishii, S. Matsuyama, K. Kusano, Y. Nozawa, S. Yamauchi, M. Karahashi, S. Oshikawa, K. Kikuchi, S. Koshio, K. Watanabe, Y. Suzuki, F. Fujishiro, A. Ishizaki, H. Sugai, A. Terakawa, Y. Kikuchi, and N. Osada. An evaluation of the radiocesiu m retentiion ability by root-mat horizon using micro PIXE analysis.[Nuclear Instruments and Methods in Physics Research B,(2013),xxx]

S. Matsuyama, K. Ishii, A. Terakawa, Y. Kikuchi, M. Fujiwara, H. Sugai, M. Karahashi, Y. Nozawa, S. Yamauchi, K. Watanabe, M. Fujisawa, M. Ishiya and T. Nagaya Improvement of the Tohoku microbeam system for nanoscopic analysis.[Nuclear Instruments and Methods in Physics Research B,(2013),xxx]

H. Sugai, K. Ishii, S. Matsuyama, A. Terakawa, Y. Kikuchi, H. Takahashi, A. Ishizaki, F. Fujishiro, H. Arai, N. Osada, M. Karahashi, Y. Nozawa, S. Yamauchi, K. Kikuchi, S. Koshio, and K. Watanabe. PIXE analysis of Cs in soil and rice plants.[Nuclear Instruments and Methods in Physics Research B,(2013),xxx]

K.Ishii, A.Terakawa, S.Matsuyama, Y.Kikuchi, F.Fujishiro, A. Ishizaki, N.Osada, H.Arai, K.Sugai, K.Nagakubo and T.Sakurada. Recovery from the radioactive pollution due to Fukushima First Nuclear Power Plant Accident.[Nuclear Instruments and Methods in Physics Research B,(2013),XXX]

S. Matsuyama, M. Fujisawa, T. Nagaya, K. Ishii, A. Terakawa, Y. Kikuchi, M. Fujiwara, K. Watanabe, M. Karahashi, Y. Nozawa, S. Yamauchi & M. Ishiya Improvement of the Energy Stability of the Tohoku Dynamitron Accelerator.[International journal of PIXE,Vol. 23(Nos. 1&2),(2013),999].



2012

Z. Li, M. Kawashita, T. Kudo and H. Kanetaka, "Sol-gel synthesis, characterization and in vitro compatibility evaluation of iron nanoparticle encapsulating-silica microspheres for hyperthermia of cancer", J. Mater. Sci.: Mater. Med., 23, 2461-2469 (2012). DOI

M. Kawashita, A. Kamitani, T. Miyazaki, N. Matsui, Z. Li, H. Kanetaka and M. Hashimoto, "Zeta potential of alumina powders with different crystalline structures in simulated body environments", Mater. Sci. Engin. C, 32, 2617-2622 (2012). DOI

Z. Li, K. Kawamura, M. Kawashita, T. Kudo, H. Kanetaka and M. Hiraoka, "In vitro heating capability, mechanical strength and biocompatibility assessment of PMMA-based bone cement containing magnetite nanoparticles for hyperthermia of cancer", J. Biomed. Mater. Res., 100A, 2537-2545 (2012). DOI

J. Hayashi, M. Kawashita, T. Miyazaki, M. Kamitakahara, K. Ioku and H. Kanetaka, "Comparison of adsorption behavior of bovine serum albumin and osteopontin on hydroxyapatite and alumina", Phosphorus Res. Bull., 26, 23-28 (2012). DOI

M. Kawashita, K. Taninai, Z. Li, K. Ishikawa and Y. Yoshida, "Preparation of low-crystalline apatite nanoparticles and their coating onto quartz substrates", J. Mater. Sci.: Mater. Med., 23, 1355-1362 (2012). DOI

T. Yokoi, H. Kato, I. Y. Kim, K. Kikuta, M. Kawashita and C. Ohtsuki, "Synthesis of octacalcium phosphate with incorporated succinate and suberate ions", Ceramics Int., 38, 3815-3820 (2012). DOI

A. S. Hamizah, M. Mariatti, R. Othman, M. Kawashita and A. R. Noor Hayati, "Mechanical and thermal properties of polymethylmethacrylate bone cement composites incorporated with hydroxyapatite and glass-ceramic fillers", J. Appl. Polym. Sci., 125, E661-669 (2012). DOI

T. Miyazaki, A. Miyaoka, E. Ishida, Z. Li, M. Kawashita and M. Hiraoka, "Preparation of ferromagnetic microcapsules for hyperthermia using water/oil emulsion as a reaction field", Mater. Sci. Engin. C, 32, 692-696 (2012). DOI

T. Yokoi, H. Kato, I. Y. Kim, K. Kikuta, M. Kamitakahara, M. Kawashita and C. Ohtsuki, "Formation of octacalcium phosphates with co-incorporated succinate and suberate ions", Dalton Trans., 41, 2732-2737 (2012). DOI

K. Takada, J. Okada, K. Nakamura, S. Yoshizawa, and S. Umemura, "High Voltage Staircase Drive Circuit for Triggered High-Intensity Focused Ultrasound Treatment," Japanese Journal of Applied Physics, vol. 51, pp. 07GF23 1-2, 2012.

K. Otsu, S. Yoshizawa, and S. Umemura, "Therapeutic Array Transducer Element Using Coresonance between Hemispherical Piezoceramic Shell and Water Sphere: Effect of Load Masses of Support and Electric Contact," Japanese Journal of Applied Physics, vol. 51, pp. 07GF24 1-6, 2012.

Y. Shimazaki, S. Harigane, S. Yoshizawa, and S. Umemura, "Three-Dimensional Quantitative Optical Measurement of Asymmetrically Focused Ultrasound Pressure Field," Japanese Journal of Applied Physics, vol. 51, pp. 07GF25 1-4, 2012. R. Matsuzawa, T. Shishitani, S. Yoshizawa, and S. Umemura, "Monitoring of Lesion Induced by High-Intensity Focused Ultrasound Using Correlation Method Based on Block Matching," Japanese Journal of Applied Physics, vol. 51, pp. 07GF26 1-6, 2012.

T. Moriyama, S. Yoshizawa, and S. Umemura, "Thermal Simulation of Cavitation-Enhanced Ultrasonic Heating Verified with Tissue-Mimicking Gel," Japanese Journal of Applied Physics, vol. 51, pp. 07GF27 1-6, 2012.

J. Shimizu, T. Fukuda, T. Abe, M. Ogihara, J. Kubota, A. Sasaki, T. Azuma, K. Sasaki, K. Shimizu, T. Oisih, S. Umemura and H. Furuhata, "Ultrasound Safety with Midfrequency Transcranial Sonothrombolysis: Preliminary Study on Normal Macaca Monkey Brain," Ultrasound in Medicine & Biology, vol. 38, no. 6, pp. 1040-1050, 2012.

K. Ichizuka, J. Hasegawa, M. Nakamura, R. Matsuoka, A. Sekizawa, T. Okai, amd S. Umemura, "High-intensity focused ultrasound treatment for twin reversed arterial perfusion sequence," ULTRASOUND IN OBSTETRICS & GYNECOLOGY, vol. 40, no. 4, pp. 476-478,2012.

N. Yumita, Y. Iwase, K. Nishi, K. Onodera, T. Fukai, T. Ikeda, S. Umemura, K. Okudaira and Y. Momose, "Involvement of Reactive Oxygen Species in Sonodynamically Induced Apoptosis Using a Novel Porphyrin Derivative,"THERANOSTICS, vol. 2, no. 9, pp. 880-888, 2012.

Y. MIURA, I. HIRAI, K. ISHII, S. MATSUYAMA, A. TERAKAWA, Y. KIKUCHI, M. FUJIWARA, H. SUGAI, S. HIRAISHI, A. FUKAYA, H. YAMAZAKI, T. TADA, K. SERA. PIXE ANALYSIS OF DYES USED IN TRADITIONAL JAPANESE CARPETS (NABESHIMA-DANTSU).[International Journal of PIXE,22(1 & 2),(2012),45-50].

H. SUGAI, K. FUJIKI, K. ISHII, S. MATSUYAMA, A. TERAKAWA, Y. KIKUCHI, M. FUJIWARA, Y. HATORI, N. HAMADA, Y. ITOH, S. HIRAISHI, Y. MIURA, A. FUKAYA, H. YAMAZAKI, T. TADA, E. SAKURAI. IMPROVEMENT OF THE DETECTION EFFICIENCY OF THE IN-AIR SUBMILLI-PIXE CAMERA FOR BIOLOGICAL APPLICATIONS.[International Journal of PIXE,22(1 & 2),(2012),37-43].

K. ISHII, A. TERAKAWA, S. MATSUYAMA, A. HASEGAWA, K. NAGAKUBO, T. SAKURADA, Y. KIKUCHI, M. FUJIWARA, H. YAMAZAKI, H. YUHKI, S. KIM, I. SATOH. MEASURES AGAINST RADIOACTIVE CONTAMINATION DUE TO FUKUSHIMA FIRST NUCLEAR POWER PLANT ACCIDENTS PART III: REMOVING AND DECONTAMINATION OF CONTAMINATED SOIL. [International Journal of PIXE,22(1 & 2),(2012),13-19].

K. ISHII, A. TERAKAWA, S. MATSUYAMA, A. HASEGAWA, K. NAGAKUBO, T. SAKURADA, Y. KIKUCHI, M. FUJIWARA, H. YAMAZAKI, H. YUHKI, S. KIM, I. SATOH. MEASURES AGAINST RADIOACTIVE CONTAMINATION DUE TO FUKUSHIMA FIRST NUCLEAR POWER PLANT ACCIDENTS PART II: MEASUREMENT OF SPACE RADIATION DOSE RATES AND EXAMINATION OF CONTAMINATION IN FOOD.[International Journal of PIXE,22(1 & 2),(2012),7-12].

K. ISHII, A. TERAKAWA, S. MATSUYAMA, A. HASEGAWA, K. NAGAKUBO, T. SAKURADA, Y. KIKUCHI, M. FUJIWARA, H. YAMAZAKI, H. YUHKI, S. KIM, I. SATOH. MEASURES AGAINST RADIOACTIVE CONTAMINATION DUE TO FUKUSHIMA FIRST NUCLEAR POWER PLANT ACCIDENTS PART I: DAMAGE SITUATION OF THE GREAT EAST JAPAN EARTHQUAKE.[International Journal of PIXE,22(1 & 2),(2012),1-5].

Terakawa A., Ishii K., Matsuyama S., Kikuchi Ito Y., Yasunaga S., Tagawa A., Kawamura T., Takahashi Y., Hatori Y., Hamada N., Fujiki K., Miura Y., Yamazaki H., Funaki Y., Itoh N., Wada S. and Sera K. A Preliminary Study of Proton Therapy Combined with Cisplatin.[CYRIC Annual Report 2010-2011,(2012),46-48].

Matsuyama S., Catella G., Ishii K., Terakawa A., Kikuchi Y., Kawamura Y., Ohkura S., Fujikawa M., Hamada N., Fujiki K., Hatori Y., Ito Y., Yamazaki H., Hashimoto Y., Zitnik M., Pelicon P., and Grlj N. Microbeam Analysis of Individual Particles in Working Environment.[CYRIC Annual Report 2010-2011,(2012),57-61].

Terakawa A., Ishii K., Matsuyama S., Kikuchi Y., Yasunaga S., Ito Y., Tagawa A., Kawamura T., Takahashi Y., Sugai H., Hamada N., Fujiki K., Hatori Y., Yamazaki H., Funaki Y., Furumoto S., Itoh N. and Wada S. PIXE Analysis of a Murine Fibrosarcoma Tumor Treated With a Vasucular Disrupting Agent AVE8062.[CYRIC Annual Report 2010-2011,(2012),49-51].